The spliceosome inhibitors isoginkgetin and pladienolide B induce ATF3-dependent cell death

The spliceosome assembles on pre-mRNA in a stepwise manner through five successive pre-spliceosome complexes. The spliceosome functions to remove introns from pre-mRNAs to generate mature mRNAs that encode functional proteins. Many small molecule inhibitors of the spliceosome have been identified an...

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Detalles Bibliográficos
Autores principales: Vanzyl, Erin J., Sayed, Hadil, Blackmore, Alex B., Rick, Kayleigh R. C., Fernando, Pasan, McKay, Bruce C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769279/
https://www.ncbi.nlm.nih.gov/pubmed/33370278
http://dx.doi.org/10.1371/journal.pone.0224953

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769279/
https://www.ncbi.nlm.nih.gov/pubmed/33370278
http://dx.doi.org/10.1371/journal.pone.0224953

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