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The spliceosome inhibitors isoginkgetin and pladienolide B induce ATF3-dependent cell death
The spliceosome assembles on pre-mRNA in a stepwise manner through five successive pre-spliceosome complexes. The spliceosome functions to remove introns from pre-mRNAs to generate mature mRNAs that encode functional proteins. Many small molecule inhibitors of the spliceosome have been identified an...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769279/ https://www.ncbi.nlm.nih.gov/pubmed/33370278 http://dx.doi.org/10.1371/journal.pone.0224953 |