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The protective mutation A673T in amyloid precursor protein gene decreases Aβ peptides production for 14 forms of Familial Alzheimer’s Disease in SH-SY5Y cells

The deposition of Aβ plaques in the brain leads to the onset and development of Alzheimer’s disease. The Amyloid precursor protein (APP) is cleaved by α-secretase (non-amyloidogenic processing of APP), however increased cleavage by β-secretase (BACE1) leads to the accumulation of Aβ peptides, which...

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Detalles Bibliográficos
Autores principales: Guyon, Antoine, Rousseau, Joël, Lamothe, Gabriel, Tremblay, Jacques P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769289/
https://www.ncbi.nlm.nih.gov/pubmed/33370284
http://dx.doi.org/10.1371/journal.pone.0237122