Lung Cancer Cells-Controlled Dkk-1 Production in Brain Metastatic Cascade Drive Microglia to Acquire a Pro-tumorigenic Phenotype

OBJECTIVES: Organotropism is primarily determined by tumor-derived exosomes. To date, the role of lung cancer cells-derived exosomes underlying the pre-metastatic niche formation is unclear. MATERIALS AND METHODS: The animal models of retro-orbital and intra-ventricular injection were constructed to...

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Detalles Bibliográficos
Autores principales: Gan, Dong-Xue, Wang, Yi-Bei, He, Ming-Yang, Chen, Zi-Yang, Qin, Xiao-Xue, Miao, Zi-Wei, Chen, Yu-Hua, Li, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769850/
https://www.ncbi.nlm.nih.gov/pubmed/33384994
http://dx.doi.org/10.3389/fcell.2020.591405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769850/
https://www.ncbi.nlm.nih.gov/pubmed/33384994
http://dx.doi.org/10.3389/fcell.2020.591405

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