Limited Mitochondrial Activity Coupled With Strong Expression of CD34, CD90 and EPCR Determines the Functional Fitness of ex vivo Expanded Human Hematopoietic Stem Cells

Ex vivo expansion strategies of human hematopoietic stem cell (HSC) grafts with suboptimal stem cell dose have emerged as promising strategies for improving outcomes of HSC transplantation in patients with hematological malignancies. While exposure of HSCs to ex vivo cultures expands the number of p...

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Detalles Bibliográficos
Autores principales: Papa, Luena, Djedaini, Mansour, Martin, Tiphaine C., Zangui, Mahtab, Beaumont, Kristin G., Sebra, Robert, Parsons, Ramon, Schaniel, Christoph, Hoffman, Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769876/
https://www.ncbi.nlm.nih.gov/pubmed/33384995
http://dx.doi.org/10.3389/fcell.2020.592348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769876/
https://www.ncbi.nlm.nih.gov/pubmed/33384995
http://dx.doi.org/10.3389/fcell.2020.592348

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