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Astrocyte HIV-1 Tat Differentially Modulates Behavior and Brain MMP/TIMP Balance During Short and Prolonged Induction in Transgenic Mice

Despite effective antiretroviral therapy (ART), mild forms of HIV-associated neurocognitive disorders (HAND) continue to afflict approximately half of all people living with HIV (PLWH). As PLWH age, HIV-associated inflammation perturbs the balance between brain matrix metalloproteinases (MMPs) and t...

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Detalles Bibliográficos
Autores principales: Joshi, Chaitanya R., Stacy, Satomi, Sumien, Nathalie, Ghorpade, Anuja, Borgmann, Kathleen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769877/
https://www.ncbi.nlm.nih.gov/pubmed/33384653
http://dx.doi.org/10.3389/fneur.2020.593188