Cargando…
MFSD12 mediates the import of cysteine into melanosomes and lysosomes
Dozens of genes contribute to the vast variation in human pigmentation. Many of these encode proteins that localize to the melanosome, the lysosome-related organelle that synthesizes pigment, but have unclear functions (1,2). Here, we describe the MelanoIP method for rapidly isolating melanosomes an...
Autores principales: | Adelmann, Charles H., Traunbauer, Anna K., Chen, Brandon, Condon, Kendall J., Chan, Sze Ham, Kunchok, Tenzin, Lewis, Caroline A., Sabatini, David M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770032/ https://www.ncbi.nlm.nih.gov/pubmed/33208952 http://dx.doi.org/10.1038/s41586-020-2937-x |
Ejemplares similares
-
MFSD12 affects glycosphingolipid metabolism by modulating lysosome homeostasis
por: Hong, Yun, et al.
Publicado: (2022) -
Dihydroxyacetone phosphate signals glucose availability to mTORC1
por: Orozco, Jose M., et al.
Publicado: (2020) -
Importance of lysosomal cysteine proteases in lung disease
por: Wolters, Paul J, et al.
Publicado: (2000) -
Histidine catabolism is a major determinant of methotrexate sensitivity
por: Kanarek, Naama, et al.
Publicado: (2018) -
Distinct Protein Sorting and Localization to Premelanosomes, Melanosomes, and Lysosomes in Pigmented Melanocytic Cells(✪)
por: Raposo, Graça, et al.
Publicado: (2001)