Anti-sortilin1 Antibody Up-Regulates Progranulin via Sortilin1 Down-Regulation

Progranulin (PGRN) haploinsufficiency associated with loss-of-function mutations in the granulin gene causes frontotemporal dementia (FTD). This suggests that increasing PGRN levels could have promising therapeutic implications for patients carrying GRN mutations. In this study, we explored the ther...

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Detalles Bibliográficos
Autores principales: Miyakawa, Shuuichi, Sakuma, Hiroyuki, Warude, Dnyaneshwar, Asanuma, Satomi, Arimura, Naoto, Yoshihara, Tomoki, Tavares, Daniel, Hata, Akito, Ida, Koh, Hori, Yuri, Okuzono, Yuumi, Yamamoto, Syunsuke, Iida, Koichi, Shimizu, Hisao, Kondo, Shinichi, Sato, Shuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770147/
https://www.ncbi.nlm.nih.gov/pubmed/33384578
http://dx.doi.org/10.3389/fnins.2020.586107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770147/
https://www.ncbi.nlm.nih.gov/pubmed/33384578
http://dx.doi.org/10.3389/fnins.2020.586107

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