BRCA1/2 Mutation Status Impact on Autophagy and Immune Response: Unheralded Target

BRCA1 and possibly BRCA2 proteins may relate to the regulation of autophagy. Autophagy plays a key role in immune response from both a tumor and immune effector cell standpoint. In cells with BRCA mutations, increased autophagy leads to elevated expression of major histocompatibility complex class I...

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Detalles Bibliográficos
Autores principales: Morand, Susan, Stanbery, Laura, Walter, Adam, Rocconi, Rodney P, Nemunaitis, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771003/
https://www.ncbi.nlm.nih.gov/pubmed/33409454
http://dx.doi.org/10.1093/jncics/pkaa077
Descripción
Sumario:BRCA1 and possibly BRCA2 proteins may relate to the regulation of autophagy. Autophagy plays a key role in immune response from both a tumor and immune effector cell standpoint. In cells with BRCA mutations, increased autophagy leads to elevated expression of major histocompatibility complex class II but may cause subclonal neoantigen presentation, which may impair the immune response related to clonal neoantigen visibility. We review evidence of BRCA1/2 regulation of autophagy, immune response, and antigen presentation.

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