BRCA1/2 Mutation Status Impact on Autophagy and Immune Response: Unheralded Target

BRCA1 and possibly BRCA2 proteins may relate to the regulation of autophagy. Autophagy plays a key role in immune response from both a tumor and immune effector cell standpoint. In cells with BRCA mutations, increased autophagy leads to elevated expression of major histocompatibility complex class I...

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Autores principales: Morand, Susan, Stanbery, Laura, Walter, Adam, Rocconi, Rodney P, Nemunaitis, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771003/
https://www.ncbi.nlm.nih.gov/pubmed/33409454
http://dx.doi.org/10.1093/jncics/pkaa077
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author Morand, Susan
Stanbery, Laura
Walter, Adam
Rocconi, Rodney P
Nemunaitis, John
author_facet Morand, Susan
Stanbery, Laura
Walter, Adam
Rocconi, Rodney P
Nemunaitis, John
author_sort Morand, Susan
collection PubMed
description BRCA1 and possibly BRCA2 proteins may relate to the regulation of autophagy. Autophagy plays a key role in immune response from both a tumor and immune effector cell standpoint. In cells with BRCA mutations, increased autophagy leads to elevated expression of major histocompatibility complex class II but may cause subclonal neoantigen presentation, which may impair the immune response related to clonal neoantigen visibility. We review evidence of BRCA1/2 regulation of autophagy, immune response, and antigen presentation.
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spelling pubmed-77710032021-01-05 BRCA1/2 Mutation Status Impact on Autophagy and Immune Response: Unheralded Target Morand, Susan Stanbery, Laura Walter, Adam Rocconi, Rodney P Nemunaitis, John JNCI Cancer Spectr Minireview BRCA1 and possibly BRCA2 proteins may relate to the regulation of autophagy. Autophagy plays a key role in immune response from both a tumor and immune effector cell standpoint. In cells with BRCA mutations, increased autophagy leads to elevated expression of major histocompatibility complex class II but may cause subclonal neoantigen presentation, which may impair the immune response related to clonal neoantigen visibility. We review evidence of BRCA1/2 regulation of autophagy, immune response, and antigen presentation. Oxford University Press 2020-08-24 /pmc/articles/PMC7771003/ /pubmed/33409454 http://dx.doi.org/10.1093/jncics/pkaa077 Text en © The Author(s) 2020. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Minireview
Morand, Susan
Stanbery, Laura
Walter, Adam
Rocconi, Rodney P
Nemunaitis, John
BRCA1/2 Mutation Status Impact on Autophagy and Immune Response: Unheralded Target
title BRCA1/2 Mutation Status Impact on Autophagy and Immune Response: Unheralded Target
title_full BRCA1/2 Mutation Status Impact on Autophagy and Immune Response: Unheralded Target
title_fullStr BRCA1/2 Mutation Status Impact on Autophagy and Immune Response: Unheralded Target
title_full_unstemmed BRCA1/2 Mutation Status Impact on Autophagy and Immune Response: Unheralded Target
title_short BRCA1/2 Mutation Status Impact on Autophagy and Immune Response: Unheralded Target
title_sort brca1/2 mutation status impact on autophagy and immune response: unheralded target
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771003/
https://www.ncbi.nlm.nih.gov/pubmed/33409454
http://dx.doi.org/10.1093/jncics/pkaa077
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