De novo synthesis of hepatitis B virus nucleocapsids is dispensable for the maintenance and transcriptional regulation of cccDNA

BACKGROUND & AIMS: Chronic HBV infection cannot be cured by current therapeutics owing to their limited ability to reduce covalently closed circular (ccc)DNA levels in the livers of infected individuals. Therefore, greater understanding of the molecular determinants of cccDNA formation and persi...

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Detalles Bibliográficos
Autores principales: Tu, Thomas, Zehnder, Benno, Qu, Bingqian, Urban, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771110/
https://www.ncbi.nlm.nih.gov/pubmed/33385130
http://dx.doi.org/10.1016/j.jhepr.2020.100195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771110/
https://www.ncbi.nlm.nih.gov/pubmed/33385130
http://dx.doi.org/10.1016/j.jhepr.2020.100195

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