The Polyphosphate Kinase of Escherichia coli Is Required for Full Production of the Genotoxin Colibactin

Colibactin induces DNA damage in mammalian cells and has been linked to the virulence of Escherichia coli and the promotion of colorectal cancer (CRC). By looking for mutants attenuated in the promoter activity of clbB encoding one of the key enzymes for the production of colibactin, we found that a...

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Detalles Bibliográficos
Autores principales: Tang-Fichaux, Min, Chagneau, Camille V., Bossuet-Greif, Nadège, Nougayrède, Jean-Philippe, Oswald, Éric, Branchu, Priscilla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771237/
https://www.ncbi.nlm.nih.gov/pubmed/33328353
http://dx.doi.org/10.1128/mSphere.01195-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771237/
https://www.ncbi.nlm.nih.gov/pubmed/33328353
http://dx.doi.org/10.1128/mSphere.01195-20

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