A Versatile Method to Determine the Cellular Bioavailability of Small-Molecule Inhibitors

The determination of the cellular bioavailability of small-molecule inhibitors is a critical step for interpreting cell-based data and guiding inhibitor optimization. Herein, a HPLC-MS based protocol was developed to determine inhibitor cellular bioavailability. This generalizable protocol allows de...

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Detalles Bibliográficos
Autores principales: Teuscher, Kevin B., Zhang, Min, Ji, Haitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771553/
https://www.ncbi.nlm.nih.gov/pubmed/27935314
http://dx.doi.org/10.1021/acs.jmedchem.6b00923

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771553/
https://www.ncbi.nlm.nih.gov/pubmed/27935314
http://dx.doi.org/10.1021/acs.jmedchem.6b00923

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