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The Implications of PDK1–4 on Tumor Energy Metabolism, Aggressiveness and Therapy Resistance
A metabolic shift from oxidative phosphorylation (OXPHOS) to glycolysis—known as the Warburg effect—is characteristic for many cancers. It gives the cancer cells a survival advantage in the hypoxic tumor microenvironment and protects them from cytotoxic effects of oxidative damage and apoptosis. The...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771695/ https://www.ncbi.nlm.nih.gov/pubmed/33384955 http://dx.doi.org/10.3389/fonc.2020.583217 |