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KF-1607, a Novel Pan Src Kinase Inhibitor, Attenuates Obstruction-Induced Tubulointerstitial Fibrosis in Mice

Src family kinases (SFKs), an important group of non-receptor tyrosine kinases, are suggested to be excessively activated during various types of tissue fibrosis. The present study investigated the effect of KF-1607, an orally active and a newly synthesized Src kinase inhibitor (SKI) with proposed l...

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Detalles Bibliográficos
Autores principales: Dorotea, Debra, Lee, Seungyeon, Lee, Sun Joo, Lee, Gayoung, Son, Jung Beom, Choi, Hwan Geun, Ahn, Sung-Min, Ha, Hunjoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771845/
https://www.ncbi.nlm.nih.gov/pubmed/32690822
http://dx.doi.org/10.4062/biomolther.2020.088