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Identification of the critical replication targets of CDK reveals direct regulation of replication initiation factors by the embryo polarity machinery in C. elegans

During metazoan development, the cell cycle is remodelled to coordinate proliferation with differentiation. Developmental cues cause dramatic changes in the number and timing of replication initiation events, but the mechanisms and physiological importance of such changes are poorly understood. Cycl...

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Detalles Bibliográficos
Autores principales: Gaggioli, Vincent, Kieninger, Manuela R., Klucnika, Anna, Butler, Richard, Zegerman, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771872/
https://www.ncbi.nlm.nih.gov/pubmed/33320862
http://dx.doi.org/10.1371/journal.pgen.1008948