Combined transient ablation and single-cell RNA-sequencing reveals the development of medullary thymic epithelial cells

Medullary thymic epithelial cells (mTECs) play a critical role in central immune tolerance by mediating negative selection of autoreactive T cells through the collective expression of the peripheral self-antigen compartment, including tissue-specific antigens (TSAs). Recent work has shown that gene-...

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Detalles Bibliográficos
Autores principales: Wells, Kristen L, Miller, Corey N, Gschwind, Andreas R, Wei, Wu, Phipps, Jonah D, Anderson, Mark S, Steinmetz, Lars M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771965/
https://www.ncbi.nlm.nih.gov/pubmed/33226342
http://dx.doi.org/10.7554/eLife.60188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771965/
https://www.ncbi.nlm.nih.gov/pubmed/33226342
http://dx.doi.org/10.7554/eLife.60188

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