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Combined transient ablation and single-cell RNA-sequencing reveals the development of medullary thymic epithelial cells

Medullary thymic epithelial cells (mTECs) play a critical role in central immune tolerance by mediating negative selection of autoreactive T cells through the collective expression of the peripheral self-antigen compartment, including tissue-specific antigens (TSAs). Recent work has shown that gene-...

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Detalles Bibliográficos
Autores principales:	Wells, Kristen L, Miller, Corey N, Gschwind, Andreas R, Wei, Wu, Phipps, Jonah D, Anderson, Mark S, Steinmetz, Lars M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2020
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7771965/ https://www.ncbi.nlm.nih.gov/pubmed/33226342 http://dx.doi.org/10.7554/eLife.60188

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