Pancreatic, but not myeloid-cell, expression of interleukin-1alpha is required for maintenance of insulin secretion and whole body glucose homeostasis

OBJECTIVE: The expression of the interleukin-1 receptor type I (IL-1R) is enriched in pancreatic islet β-cells, signifying that ligands activating this pathway are important for the health and function of the insulin-secreting cell. Using isolated mouse, rat, and human islets, we identified the cyto...

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Detalles Bibliográficos
Autores principales: Collier, J. Jason, Batdorf, Heidi M., Martin, Thomas M., Rohli, Kristen E., Burk, David H., Lu, Danhong, Cooley, Chris R., Karlstad, Michael D., Jackson, Joseph W., Sparer, Tim E., Zhang, Jingying, Mynatt, Randall L., Burke, Susan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772372/
https://www.ncbi.nlm.nih.gov/pubmed/33285301
http://dx.doi.org/10.1016/j.molmet.2020.101140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772372/
https://www.ncbi.nlm.nih.gov/pubmed/33285301
http://dx.doi.org/10.1016/j.molmet.2020.101140

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