Cargando…

Donor-Specific Transcriptomic Analysis of Alzheimer's Disease-Associated Hypometabolism Highlights a Unique Donor, Ribosomal Proteins and Microglia

Alzheimer’s disease (AD) starts decades before clinical symptoms appear. Low-glucose utilization in regions of the cerebral cortex marks early AD. To identify these regions, we conducted a voxel-wise meta-analysis of previous studies conducted with positron emission tomography that compared AD patie...

Descripción completa

Detalles Bibliográficos
Autores principales:	Patel, Sejal, Howard, Derek, Man, Alana, Schwartz, Deborah, Jee, Joelle, Felsky, Daniel, Pausova, Zdenka, Paus, Tomas, French, Leon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Society for Neuroscience 2020
Materias:	Research Article: New Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772516/ https://www.ncbi.nlm.nih.gov/pubmed/33234543 http://dx.doi.org/10.1523/ENEURO.0255-20.2020

Ejemplares similares

Characterization of Human Genes Modulated by Porphyromonas gingivalis Highlights the Ribosome, Hypothalamus, and Cholinergic Neurons
por: Patel, Sejal, et al.
Publicado: (2021)

The combined effects of microglia activation and brain glucose hypometabolism in early-onset Alzheimer’s disease
por: Tondo, Giacomo, et al.
Publicado: (2020)

Intraoperative anaphylaxis—highlighting the dilemmas in living donor nephrectomy
por: Muralidhar, V, et al.
Publicado: (2020)

The genetics of a “femaleness/maleness” score in cardiometabolic traits in the UK biobank
por: Vosberg, Daniel E., et al.
Publicado: (2023)

Localization of TRP Channels in Healthy Oral Mucosa from Human Donors
por: Moayedi, Yalda, et al.
Publicado: (2022)

Identification of the novel HLA‐C*07:02:01:115 allele in a volunteer bone marrow donor
por: Ulrich, Silvia, et al.
Publicado: (2021)

Investigating microglia-neuron crosstalk by characterizing microglial contamination in human and mouse patch-seq datasets
por: Arbabi, Keon, et al.
Publicado: (2023)

Microglia Enhance Synapse Activity to Promote Local Network Synchronization
por: Akiyoshi, Ryohei, et al.
Publicado: (2018)

Donor cell-derived genetic abnormalities after sex mismatched allogeneic cell transplantation: a unique challenge of donor cell leukemia
por: Klausner, Melanie, et al.
Publicado: (2023)

Hypometabolism as a therapeutic target in Alzheimer's disease
por: Costantini, Lauren C, et al.
Publicado: (2008)

Poisson Noise Obscures Hypometabolic Lesions in PET
por: Kerr, Wesley T., et al.
Publicado: (2012)

Mirror writing and cortical hypometabolism in Parkinson’s disease
por: Shinohara, Mayumi, et al.
Publicado: (2022)

The novel HLA‐A*24 allele, HLA‐A*24:487, identified in three unrelated bone marrow donors in Colombia
por: Hernández, David Guillermo, et al.
Publicado: (2021)

Donor Cancer Transmission in Kidney Transplantation
por: Baudoux, Thomas E.R., et al.
Publicado: (2016)

Visceral fat is associated with lower executive functioning in adolescents
por: Schwartz, Deborah H., et al.
Publicado: (2013)

Acceptance of Donor Eggs, Donor Sperms, or Donor Embryos in Indian Infertile Couples
por: Banerjee, Kaberi, et al.
Publicado: (2018)

Adult Living-Donor Kidney Transplantation, Donor Age, and Donor–Recipient Age
por: Hiramitsu, Takahisa, et al.
Publicado: (2021)

The healthy donor effect and survey participation, becoming a donor and donor career
por: Brodersen, Thorsten, et al.
Publicado: (2022)

General Psychopathology, Cognition, and the Cerebral Cortex in 10-Year-Old Children: Insights From the Adolescent Brain Cognitive Development Study
por: Patel, Yash, et al.
Publicado: (2022)

Obesity-Related Neuroinflammation: Magnetic Resonance and Microscopy Imaging of the Brain
por: Woo, Anita, et al.
Publicado: (2022)

Haematological quality and age of donor blood issued for paediatric transfusion to four hospitals in sub‐Saharan Africa
por: Uyoga, Sophie, et al.
Publicado: (2019)

Morphological and Phagocytic Profile of Microglia in the Developing Rat Cerebellum1,2,3
por: Perez-Pouchoulen, Miguel, et al.
Publicado: (2015)

Regulation of Physical Microglia–Neuron Interactions by Fractalkine Signaling after Status Epilepticus
por: Eyo, Ukpong B., et al.
Publicado: (2017)

Electroconvulsive Shock Enhances Responsive Motility and Purinergic Currents in Microglia in the Mouse Hippocampus
por: Sepulveda-Rodriguez, Alberto, et al.
Publicado: (2019)

Commentary: Evolution of pediatric living-donor lung transplant: Adaptation to unique environment
por: Adachi, Iki, et al.
Publicado: (2020)

Differentiation of Donor-Derived Cells Into Microglia After Umbilical Cord Blood Stem Cell Transplantation
por: Takahashi, Kazuya, et al.
Publicado: (2015)

Donor heart selection: the outcome of "unacceptable" donors
por: Khasati, Noman H, et al.
Publicado: (2007)

Family/friend donors are not true voluntary donors
por: Jain, Rohit, et al.
Publicado: (2012)

Donor Infection: An Opinion on Lung Donor Utilization
por: Garrity, Edward R., et al.
Publicado: (2005)

Partial 18S ribosomal DNA sequences of nematode species collected in South Korea
por: Yoon, Jihye, et al.
Publicado: (2022)

The Significance of Insular Hypometabolism in Temporal Lobe Epilepsy in Children
por: Hur, Ji Ae, et al.
Publicado: (2013)

Hypometabolism of the posterior cingulate cortex is not restricted to Alzheimer's disease
por: Scheltens, Nienke M.E., et al.
Publicado: (2018)

Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer disease
por: Ng, Kok Pin, et al.
Publicado: (2017)

Mechanosensation of the heart and gut elicits hypometabolism and vigilance in mice
por: Scott, Karen A., et al.
Publicado: (2023)

Hypometabolism, Alzheimer’s Disease, and Possible Therapeutic Targets: An Overview
por: Raut, Snehal, et al.
Publicado: (2023)

Plant hexokinase phylogenetic analysis highlights a possible regulation by the posttranslational modifier SUMO
por: Castro, Pedro Humberto, et al.
Publicado: (2020)

Cumulative sum analysis of the learning curve for video-assisted minilaparotomy donor nephrectomy in healthy kidney donors
por: Park, Jee Soo, et al.
Publicado: (2018)

Donor Smoking Negatively Affects Donor and Recipient Renal Function following Living Donor Nephrectomy
por: Heldt, Jonathan, et al.
Publicado: (2011)

Donor and non‐donor perspectives on receiving information from routine genomic testing of donor blood
por: Thorpe, Rachel, et al.
Publicado: (2022)

Investigating the Effects of Donors and Alkyne Spacer on the Properties of Donor-Acceptor-Donor Xanthene-Based Dyes
por: Rajapaksha, Ishanka N., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_da49rdbao3rqoveb1dcugg6th4