Identification of cGAS as an innate immune sensor of extracellular bacterium Pseudomonas aeruginosa

Cyclic GMP-AMP synthase (cGAS) is reported essential for detecting intracellular bacteria. However, it remains to be determined whether and how cGAS is involved in extracellular bacterial infection. Here, we report that cGAS is essential for mediating type I interferon (IFN) production in infection...

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Detalles Bibliográficos
Autores principales: Zhou, Chuan-min, Wang, Biao, Wu, Qun, Lin, Ping, Qin, Shu-gang, Pu, Qin-qin, Yu, Xue-jie, Wu, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772558/
https://www.ncbi.nlm.nih.gov/pubmed/33385121
http://dx.doi.org/10.1016/j.isci.2020.101928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772558/
https://www.ncbi.nlm.nih.gov/pubmed/33385121
http://dx.doi.org/10.1016/j.isci.2020.101928

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