Genomic GLO1 deletion modulates TXNIP expression, glucose metabolism, and redox homeostasis while accelerating human A375 malignant melanoma tumor growth

Glyoxalase 1 (encoded by GLO1) is a glutathione-dependent enzyme detoxifying the glycolytic byproduct methylglyoxal (MG), an oncometabolite involved in metabolic reprogramming. Recently, we have demonstrated that GLO1 is overexpressed in human malignant melanoma cells and patient tumors and substant...

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Detalles Bibliográficos
Autores principales: Jandova, Jana, Wondrak, Georg T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772567/
https://www.ncbi.nlm.nih.gov/pubmed/33360689
http://dx.doi.org/10.1016/j.redox.2020.101838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772567/
https://www.ncbi.nlm.nih.gov/pubmed/33360689
http://dx.doi.org/10.1016/j.redox.2020.101838

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