A redox-mediated conformational change in NQO1 controls binding to microtubules and α-tubulin acetylation

The localization of NQO1 near acetylated microtubules has led to the hypothesis that NQO1 may work in concert with the NAD(+)-dependent deacetylase SIRT2 to regulate acetyl α-tubulin (K(40)) levels on microtubules. NQO1 catalyzes the oxidation of NADH to NAD(+) and may supplement levels of NAD(+) ne...

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Detalles Bibliográficos
Autores principales: Siegel, David, Bersie, Stephanie, Harris, Peter, Di Francesco, Andrea, Armstrong, Michael, Reisdorph, Nichole, Bernier, Michel, de Cabo, Rafael, Fritz, Kristofer, Ross, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772575/
https://www.ncbi.nlm.nih.gov/pubmed/33360352
http://dx.doi.org/10.1016/j.redox.2020.101840

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772575/
https://www.ncbi.nlm.nih.gov/pubmed/33360352
http://dx.doi.org/10.1016/j.redox.2020.101840

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