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HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails

G protein-coupled receptors (GPCRs) are the most common pharmacological target in human clinical practice. To perform their functions, many GPCRs must accumulate inside primary cilia, microtubule-based plasma membrane protrusions working as cellular antennae. Nevertheless, the molecular mechanisms u...

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Detalles Bibliográficos
Autores principales: Barbeito, Pablo, Tachibana, Yuki, Martin-Morales, Raquel, Moreno, Paula, Mykytyn, Kirk, Kobayashi, Tetsuo, Garcia-Gonzalo, Francesc R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7772773/
https://www.ncbi.nlm.nih.gov/pubmed/33372037
http://dx.doi.org/10.26508/lsa.202000746