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Structures and pH sensing mechanism of proton-activated chloride channel
The activity of the proton-activated chloride channel (PAC) is widespread and is involved in acid-induced cell death and tissue injury(12,3). Its molecular identity has recently been identified as a novel and evolutionarily conserved protein family(4,5). We present two cryo-EM structures of human PA...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773282/ https://www.ncbi.nlm.nih.gov/pubmed/33149300 http://dx.doi.org/10.1038/s41586-020-2875-7 |