Defective lysosome reformation during autophagy causes skeletal muscle disease

The regulation of autophagy-dependent lysosome homeostasis in vivo is unclear. We showed that the inositol polyphosphate 5-phosphatase INPP5K regulates autophagic lysosome reformation (ALR), a lysosome recycling pathway, in muscle. INPP5K hydrolyzes phosphatidylinositol-4,5-bisphosphate [PI(4,5)P(2)...

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Detalles Bibliográficos
Autores principales: McGrath, Meagan J., Eramo, Matthew J., Gurung, Rajendra, Sriratana, Absorn, Gehrig, Stefan M., Lynch, Gordon S., Lourdes, Sonia Raveena, Koentgen, Frank, Feeney, Sandra J., Lazarou, Michael, McLean, Catriona A., Mitchell, Christina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773396/
https://www.ncbi.nlm.nih.gov/pubmed/33119550
http://dx.doi.org/10.1172/JCI135124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773396/
https://www.ncbi.nlm.nih.gov/pubmed/33119550
http://dx.doi.org/10.1172/JCI135124

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