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Computational design of SARS-CoV-2 spike glycoproteins to increase immunogenicity by T cell epitope engineering

The development of effective and safe vaccines is the ultimate way to efficiently stop the ongoing COVID-19 pandemic, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Built on the fact that SARS-CoV-2 utilizes the association of its Spike (S) protein with the human an...

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Detalles Bibliográficos
Autores principales: Ong, Edison, Huang, Xiaoqiang, Pearce, Robin, Zhang, Yang, He, Yongqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773544/
https://www.ncbi.nlm.nih.gov/pubmed/33398234
http://dx.doi.org/10.1016/j.csbj.2020.12.039