RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions

Regulator of telomere length 1 (RTEL1) is an essential helicase that maintains telomere integrity and facilitates DNA replication. The source of replication stress in Rtel1-deficient cells remains unclear. Here, we report that loss of RTEL1 confers extensive transcriptional changes independent of it...

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Detalles Bibliográficos
Autores principales: Kotsantis, Panagiotis, Segura-Bayona, Sandra, Margalef, Pol, Marzec, Paulina, Ruis, Phil, Hewitt, Graeme, Bellelli, Roberto, Patel, Harshil, Goldstone, Robert, Poetsch, Anna R., Boulton, Simon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773548/
https://www.ncbi.nlm.nih.gov/pubmed/33357438
http://dx.doi.org/10.1016/j.celrep.2020.108546

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773548/
https://www.ncbi.nlm.nih.gov/pubmed/33357438
http://dx.doi.org/10.1016/j.celrep.2020.108546

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