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Structural Differences in Translation Initiation between Pathogenic Trypanosomatids and Their Mammalian Hosts
Canonical mRNA translation in eukaryotes begins with the formation of the 43S pre-initiation complex (PIC). Its assembly requires binding of initiator Met-tRNA(i)(Met) and several eukaryotic initiation factors (eIFs) to the small ribosomal subunit (40S). Compared to their mammalian hosts, trypanosom...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773551/ https://www.ncbi.nlm.nih.gov/pubmed/33357443 http://dx.doi.org/10.1016/j.celrep.2020.108534 |