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Cognitive reserve hypothesis in frontotemporal dementia: A FDG-PET study

BACKGROUND AND OBJECTIVE: Reserve is defined as the ability to maintain cognitive functions relatively well at a given level of pathology. Early life experiences such as education are associated with lower dementia risk in general. However, whether more years of education guards against the impact o...

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Autores principales: Beyer, Leonie, Meyer-Wilmes, Johanna, Schönecker, Sonja, Schnabel, Jonas, Sauerbeck, Julia, Scheifele, Maximilian, Prix, Catharina, Unterrainer, Marcus, Catak, Cihan, Pogarell, Oliver, Palleis, Carla, Perneczky, Robert, Danek, Adrian, Buerger, Katharina, Bartenstein, Peter, Levin, Johannes, Rominger, Axel, Ewers, Michael, Brendel, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773557/
https://www.ncbi.nlm.nih.gov/pubmed/33369564
http://dx.doi.org/10.1016/j.nicl.2020.102535
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author Beyer, Leonie
Meyer-Wilmes, Johanna
Schönecker, Sonja
Schnabel, Jonas
Sauerbeck, Julia
Scheifele, Maximilian
Prix, Catharina
Unterrainer, Marcus
Catak, Cihan
Pogarell, Oliver
Palleis, Carla
Perneczky, Robert
Danek, Adrian
Buerger, Katharina
Bartenstein, Peter
Levin, Johannes
Rominger, Axel
Ewers, Michael
Brendel, Matthias
author_facet Beyer, Leonie
Meyer-Wilmes, Johanna
Schönecker, Sonja
Schnabel, Jonas
Sauerbeck, Julia
Scheifele, Maximilian
Prix, Catharina
Unterrainer, Marcus
Catak, Cihan
Pogarell, Oliver
Palleis, Carla
Perneczky, Robert
Danek, Adrian
Buerger, Katharina
Bartenstein, Peter
Levin, Johannes
Rominger, Axel
Ewers, Michael
Brendel, Matthias
author_sort Beyer, Leonie
collection PubMed
description BACKGROUND AND OBJECTIVE: Reserve is defined as the ability to maintain cognitive functions relatively well at a given level of pathology. Early life experiences such as education are associated with lower dementia risk in general. However, whether more years of education guards against the impact of brain alterations also in frontotemporal dementia (FTD) has not been shown in a large patient collective. Therefore, we assessed whether education is associated with relatively high cognitive performance despite the presence of [(18)F]-fluorodeoxyglucose positron-emission-tomography (FDG-PET) hypometabolism in FTD. METHODS: Sixty-six FTD subjects (age 67 ± 8 years) and twenty-four cognitively healthy controls (HC) were evaluated. Brain regions with FTD-related glucose hypometabolism in the contrast against HC and brain regions that correlate with the cognitive function were defined by a voxel-based analysis and individual FDG-PET values were extracted from all frontotemporal brain areas. Linear regression analysis served to test if education is associated with residualized cognitive performance and regional FDG-PET hypometabolism after controlling for global cognition. RESULTS: Compared to healthy controls, patients with FTD showed glucose hypometabolism in bilateral frontal and temporal brain areas whereas cognition was only associated with deteriorated glucose metabolism in the left temporal lobe. The education level was significantly correlated with the residualized cognitive performance (residuals from regression analysis between hypometabolism and cognitive function as a quantitative index of reserve) and also negatively correlated with left temporal FDG-PET hypometabolism after controlling for cognition. CONCLUSIONS: In patients with FTD, the education level predicts the existing left temporal FDG-PET hypometabolism at the same cognition level, supporting the cognitive reserve hypothesis in FTD.
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spelling pubmed-77735572020-12-31 Cognitive reserve hypothesis in frontotemporal dementia: A FDG-PET study Beyer, Leonie Meyer-Wilmes, Johanna Schönecker, Sonja Schnabel, Jonas Sauerbeck, Julia Scheifele, Maximilian Prix, Catharina Unterrainer, Marcus Catak, Cihan Pogarell, Oliver Palleis, Carla Perneczky, Robert Danek, Adrian Buerger, Katharina Bartenstein, Peter Levin, Johannes Rominger, Axel Ewers, Michael Brendel, Matthias Neuroimage Clin Regular Article BACKGROUND AND OBJECTIVE: Reserve is defined as the ability to maintain cognitive functions relatively well at a given level of pathology. Early life experiences such as education are associated with lower dementia risk in general. However, whether more years of education guards against the impact of brain alterations also in frontotemporal dementia (FTD) has not been shown in a large patient collective. Therefore, we assessed whether education is associated with relatively high cognitive performance despite the presence of [(18)F]-fluorodeoxyglucose positron-emission-tomography (FDG-PET) hypometabolism in FTD. METHODS: Sixty-six FTD subjects (age 67 ± 8 years) and twenty-four cognitively healthy controls (HC) were evaluated. Brain regions with FTD-related glucose hypometabolism in the contrast against HC and brain regions that correlate with the cognitive function were defined by a voxel-based analysis and individual FDG-PET values were extracted from all frontotemporal brain areas. Linear regression analysis served to test if education is associated with residualized cognitive performance and regional FDG-PET hypometabolism after controlling for global cognition. RESULTS: Compared to healthy controls, patients with FTD showed glucose hypometabolism in bilateral frontal and temporal brain areas whereas cognition was only associated with deteriorated glucose metabolism in the left temporal lobe. The education level was significantly correlated with the residualized cognitive performance (residuals from regression analysis between hypometabolism and cognitive function as a quantitative index of reserve) and also negatively correlated with left temporal FDG-PET hypometabolism after controlling for cognition. CONCLUSIONS: In patients with FTD, the education level predicts the existing left temporal FDG-PET hypometabolism at the same cognition level, supporting the cognitive reserve hypothesis in FTD. Elsevier 2020-12-16 /pmc/articles/PMC7773557/ /pubmed/33369564 http://dx.doi.org/10.1016/j.nicl.2020.102535 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Regular Article
Beyer, Leonie
Meyer-Wilmes, Johanna
Schönecker, Sonja
Schnabel, Jonas
Sauerbeck, Julia
Scheifele, Maximilian
Prix, Catharina
Unterrainer, Marcus
Catak, Cihan
Pogarell, Oliver
Palleis, Carla
Perneczky, Robert
Danek, Adrian
Buerger, Katharina
Bartenstein, Peter
Levin, Johannes
Rominger, Axel
Ewers, Michael
Brendel, Matthias
Cognitive reserve hypothesis in frontotemporal dementia: A FDG-PET study
title Cognitive reserve hypothesis in frontotemporal dementia: A FDG-PET study
title_full Cognitive reserve hypothesis in frontotemporal dementia: A FDG-PET study
title_fullStr Cognitive reserve hypothesis in frontotemporal dementia: A FDG-PET study
title_full_unstemmed Cognitive reserve hypothesis in frontotemporal dementia: A FDG-PET study
title_short Cognitive reserve hypothesis in frontotemporal dementia: A FDG-PET study
title_sort cognitive reserve hypothesis in frontotemporal dementia: a fdg-pet study
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773557/
https://www.ncbi.nlm.nih.gov/pubmed/33369564
http://dx.doi.org/10.1016/j.nicl.2020.102535
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