Caspase-8 Inhibition Prevents the Cleavage and Degradation of E3 Ligase Substrate Receptor Cereblon and Potentiates Its Biological Function

Cereblon (CRBN), a substrate receptor of cullin 4-RING E3 ligase (CRL4), mediates the ubiquitination and degradation of constitutive substrates and immunomodulatory drug-induced neo-substrates including MEIS2, c-Jun, CLC1, IKZF1/3, CK1α, and SALL4. It has been reported that CRBN itself could be degr...

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Detalles Bibliográficos
Autores principales: Zhou, Liang, Yu, Wenjun, Jayabalan, David S., Niesvizky, Ruben, Jaffrey, Samie R., Huang, Xiangao, Xu, Guoqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773819/
https://www.ncbi.nlm.nih.gov/pubmed/33392195
http://dx.doi.org/10.3389/fcell.2020.605989

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773819/
https://www.ncbi.nlm.nih.gov/pubmed/33392195
http://dx.doi.org/10.3389/fcell.2020.605989

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