Insights Into the Binding Mechanism of GC7 to Deoxyhypusine Synthase in Sulfolobus solfataricus: A Thermophilic Model for the Design of New Hypusination Inhibitors

Translation factor 5A (eIF5A) is one of the most conserved proteins involved in protein synthesis. It plays a key role during the elongation of polypeptide chains, and its activity is critically dependent on hypusination, a post-translational modification of a specific lysine residue through two con...

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Detalles Bibliográficos
Autores principales: D'Agostino, Mattia, Motta, Stefano, Romagnoli, Alice, Orlando, Patrick, Tiano, Luca, La Teana, Anna, Di Marino, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773846/
https://www.ncbi.nlm.nih.gov/pubmed/33392152
http://dx.doi.org/10.3389/fchem.2020.609942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773846/
https://www.ncbi.nlm.nih.gov/pubmed/33392152
http://dx.doi.org/10.3389/fchem.2020.609942

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