Transcriptional, Behavioral and Biochemical Profiling in the 3xTg-AD Mouse Model Reveals a Specific Signature of Amyloid Deposition and Functional Decline in Alzheimer’s Disease

Alzheimer’s disease (AD)-related degenerative decline is associated to the presence of amyloid beta (Aβ) plaque lesions and neuro fibrillary tangles (NFT). However, the precise molecular mechanisms linking Aβ deposition and neurological decline are still unclear. Here we combine genome-wide transcri...

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Detalles Bibliográficos
Autores principales: Yin, Wencheng, Cerda-Hernández, Navei, Castillo-Morales, Atahualpa, Ruiz-Tejada-Segura, Mayra L., Monzón-Sandoval, Jimena, Moreno-Castilla, Perla, Pérez-Ortega, Rodrigo, Bermudez-Rattoni, Federico, Urrutia, Araxi O., Gutiérrez, Humberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774037/
https://www.ncbi.nlm.nih.gov/pubmed/33390887
http://dx.doi.org/10.3389/fnins.2020.602642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774037/
https://www.ncbi.nlm.nih.gov/pubmed/33390887
http://dx.doi.org/10.3389/fnins.2020.602642

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