Cargando…
Development of a Corneal Bioluminescence Mouse for Real-Time In Vivo Evaluation of Gene Therapies
PURPOSE: The purpose of this study was to develop and characterize a novel bioluminescence transgenic mouse model that facilitates rapid evaluation of genetic medicine delivery methods for inherited and acquired corneal diseases. METHODS: Corneal expression of the firefly luciferase transgene (luc2)...
Autores principales: | Fu, Dun Jack, Allen, Edwin H. A., Hickerson, Robyn P., Leslie Pedrioli, Deena M., McLean, W. H. Irwin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Association for Research in Vision and Ophthalmology
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774114/ https://www.ncbi.nlm.nih.gov/pubmed/33442498 http://dx.doi.org/10.1167/tvst.9.13.44 |
Ejemplares similares
-
In vivo gene silencing following non-invasive siRNA delivery into the skin using a novel topical formulation
por: Hegde, Vikas, et al.
Publicado: (2014) -
Keratin 12 missense mutation induces the unfolded protein response and apoptosis in Meesmann epithelial corneal dystrophy
por: Allen, Edwin H.A., et al.
Publicado: (2016) -
Keratin 9 Is Required for the Structural Integrity and Terminal Differentiation of the Palmoplantar Epidermis
por: Fu, Dun Jack, et al.
Publicado: (2014) -
Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis
por: Martínez-Fábregas, Jonathan, et al.
Publicado: (2018) -
Bioluminescence for in vivo detection of cell-type-specific inflammation in a mouse model of uveitis
por: John, Sarah, et al.
Publicado: (2020)