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Fatal Case of Chronic Jamestown Canyon Virus Encephalitis Diagnosed by Metagenomic Sequencing in Patient Receiving Rituximab
A 56-year-old man receiving rituximab who had months of neurologic symptoms was found to have Jamestown Canyon virus in cerebrospinal fluid by clinical metagenomic sequencing. The patient died, and postmortem examination revealed extensive neuropathologic abnormalities. Deep sequencing enabled detai...
| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Centers for Disease Control and Prevention
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774567/ https://www.ncbi.nlm.nih.gov/pubmed/33261720 http://dx.doi.org/10.3201/eid2701.203448 |
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| author | Solomon, Isaac H. Ganesh, Vijay S. Yu, Guixia Deng, Xian Ding Wilson, Michael R. Miller, Steve Milligan, Tracey A. Mukerji, Shibani S. Mathewson, Abigail Linxweiler, Justin Morse, Darlene Ritter, Jana M. Staples, J. Erin Hughes, Holly Gould, Carolyn V. Sabeti, Pardis C. Chiu, Charles Y. Piantadosi, Anne |
| author_facet | Solomon, Isaac H. Ganesh, Vijay S. Yu, Guixia Deng, Xian Ding Wilson, Michael R. Miller, Steve Milligan, Tracey A. Mukerji, Shibani S. Mathewson, Abigail Linxweiler, Justin Morse, Darlene Ritter, Jana M. Staples, J. Erin Hughes, Holly Gould, Carolyn V. Sabeti, Pardis C. Chiu, Charles Y. Piantadosi, Anne |
| author_sort | Solomon, Isaac H. |
| collection | PubMed |
| description | A 56-year-old man receiving rituximab who had months of neurologic symptoms was found to have Jamestown Canyon virus in cerebrospinal fluid by clinical metagenomic sequencing. The patient died, and postmortem examination revealed extensive neuropathologic abnormalities. Deep sequencing enabled detailed characterization of viral genomes from the cerebrospinal fluid, cerebellum, and cerebral cortex. |
| format | Online Article Text |
| id | pubmed-7774567 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Centers for Disease Control and Prevention |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-77745672021-01-01 Fatal Case of Chronic Jamestown Canyon Virus Encephalitis Diagnosed by Metagenomic Sequencing in Patient Receiving Rituximab Solomon, Isaac H. Ganesh, Vijay S. Yu, Guixia Deng, Xian Ding Wilson, Michael R. Miller, Steve Milligan, Tracey A. Mukerji, Shibani S. Mathewson, Abigail Linxweiler, Justin Morse, Darlene Ritter, Jana M. Staples, J. Erin Hughes, Holly Gould, Carolyn V. Sabeti, Pardis C. Chiu, Charles Y. Piantadosi, Anne Emerg Infect Dis Dispatch A 56-year-old man receiving rituximab who had months of neurologic symptoms was found to have Jamestown Canyon virus in cerebrospinal fluid by clinical metagenomic sequencing. The patient died, and postmortem examination revealed extensive neuropathologic abnormalities. Deep sequencing enabled detailed characterization of viral genomes from the cerebrospinal fluid, cerebellum, and cerebral cortex. Centers for Disease Control and Prevention 2021-01 /pmc/articles/PMC7774567/ /pubmed/33261720 http://dx.doi.org/10.3201/eid2701.203448 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
| spellingShingle | Dispatch Solomon, Isaac H. Ganesh, Vijay S. Yu, Guixia Deng, Xian Ding Wilson, Michael R. Miller, Steve Milligan, Tracey A. Mukerji, Shibani S. Mathewson, Abigail Linxweiler, Justin Morse, Darlene Ritter, Jana M. Staples, J. Erin Hughes, Holly Gould, Carolyn V. Sabeti, Pardis C. Chiu, Charles Y. Piantadosi, Anne Fatal Case of Chronic Jamestown Canyon Virus Encephalitis Diagnosed by Metagenomic Sequencing in Patient Receiving Rituximab |
| title | Fatal Case of Chronic Jamestown Canyon Virus Encephalitis Diagnosed by Metagenomic Sequencing in Patient Receiving Rituximab |
| title_full | Fatal Case of Chronic Jamestown Canyon Virus Encephalitis Diagnosed by Metagenomic Sequencing in Patient Receiving Rituximab |
| title_fullStr | Fatal Case of Chronic Jamestown Canyon Virus Encephalitis Diagnosed by Metagenomic Sequencing in Patient Receiving Rituximab |
| title_full_unstemmed | Fatal Case of Chronic Jamestown Canyon Virus Encephalitis Diagnosed by Metagenomic Sequencing in Patient Receiving Rituximab |
| title_short | Fatal Case of Chronic Jamestown Canyon Virus Encephalitis Diagnosed by Metagenomic Sequencing in Patient Receiving Rituximab |
| title_sort | fatal case of chronic jamestown canyon virus encephalitis diagnosed by metagenomic sequencing in patient receiving rituximab |
| topic | Dispatch |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774567/ https://www.ncbi.nlm.nih.gov/pubmed/33261720 http://dx.doi.org/10.3201/eid2701.203448 |
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