Cargando…
Harmine enhances the activity of the HIV-1 latency-reversing agents ingenol A and SAHA
Infection with human immunodeficiency virus 1 (HIV-1) remains incurable because long-lived, latently-infected cells persist during prolonged antiretroviral therapy. Attempts to pharmacologically reactivate and purge the latent reservoir with latency reactivating agents (LRAs) such as protein kinase...
Autores principales: | Taylor, Jared P., Armitage, Lucas H., Aldridge, Daniel L., Cash, Melanie N., Wallet, Mark A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Ltd
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774897/ https://www.ncbi.nlm.nih.gov/pubmed/33234703 http://dx.doi.org/10.1242/bio.052969 |
Ejemplares similares
-
Reactivation of HIV-1 from Latency by an Ingenol Derivative from Euphorbia Kansui
por: Wang, Pengfei, et al.
Publicado: (2017) -
An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression
por: Darcis, Gilles, et al.
Publicado: (2015) -
NSC95397 is a Novel HIV Latency Reversing Agent
por: Nichols Doyle, Randilea, et al.
Publicado: (2023) -
The latency-reversing agent HODHBt synergizes with IL-15 to enhance cytotoxic function of HIV-specific T cells
por: Copertino, Dennis C., et al.
Publicado: (2023) -
CRISPR/Cas9 knockout of USP18 enhances type I IFN responsiveness and restricts HIV‐1 infection in macrophages
por: Taylor, Jared P., et al.
Publicado: (2018)