Modulating the endoplasmic reticulum stress response attenuates neurodegeneration in a Caenorhabditis elegans model of spinal muscular atrophy

Spinal muscular atrophy (SMA) is a devastating autosomal recessive neuromuscular disease resulting in muscle atrophy and neurodegeneration, and is the leading genetic cause of infant death. SMA arises when there are homozygous deletion mutations in the human SMN1 gene, leading to a decrease in corre...

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Detalles Bibliográficos
Autores principales: Doyle, James J., Vrancx, Celine, Maios, Claudia, Labarre, Audrey, Patten, Shunmoogum A., Parker, J. Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774902/
https://www.ncbi.nlm.nih.gov/pubmed/33106327
http://dx.doi.org/10.1242/dmm.041350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774902/
https://www.ncbi.nlm.nih.gov/pubmed/33106327
http://dx.doi.org/10.1242/dmm.041350

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