Development of orally disintegrating tablets containing solid dispersion of a poorly soluble drug for enhanced dissolution: In-vitro optimization/in-vivo evaluation

Diacerein (DCN), a potent anti-inflammatory API used to treat osteoarthritis yet, it suffers from poor water solubility which affects its oral absorption. Unabsorbed colonic DCN is converted into rhein, which is responsible for laxation as a main side effect of DCN treatment. Therefore, in this stud...

Descripción completa

Detalles Bibliográficos
Autores principales: Fouad, Shahinaze A., Malaak, Fady A., El-Nabarawi, Mohamed A., Abu Zeid, Khalid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774920/
https://www.ncbi.nlm.nih.gov/pubmed/33382789
http://dx.doi.org/10.1371/journal.pone.0244646

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774920/
https://www.ncbi.nlm.nih.gov/pubmed/33382789
http://dx.doi.org/10.1371/journal.pone.0244646

Ejemplares similares