Pharmaco-Optogenetic Targeting of TRPC Activity Allows for Precise Control Over Mast Cell NFAT Signaling

Canonical transient receptor potential (TRPC) channels are considered as elements of the immune cell Ca(2+) handling machinery. We therefore hypothesized that TRPC photopharmacology may enable uniquely specific modulation of immune responses. Utilizing a recently established TRPC3/6/7 selective, pho...

Descripción completa

Detalles Bibliográficos
Autores principales: Bacsa, Bernadett, Graziani, Annarita, Krivic, Denis, Wiedner, Patrick, Malli, Roland, Rauter, Thomas, Tiapko, Oleksandra, Groschner, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775509/
https://www.ncbi.nlm.nih.gov/pubmed/33391284
http://dx.doi.org/10.3389/fimmu.2020.613194

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775509/
https://www.ncbi.nlm.nih.gov/pubmed/33391284
http://dx.doi.org/10.3389/fimmu.2020.613194

Ejemplares similares