Synthetic lethality across normal tissues is strongly associated with cancer risk, onset, and tumor suppressor specificity

Various characteristics of cancers exhibit tissue specificity, including lifetime cancer risk, onset age, and cancer driver genes. Previously, the large variation in cancer risk across human tissues was found to strongly correlate with the number of stem cell divisions and abnormal DNA methylation l...

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Detalles Bibliográficos
Autores principales: Cheng, Kuoyuan, Nair, Nishanth Ulhas, Lee, Joo Sang, Ruppin, Eytan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775773/
https://www.ncbi.nlm.nih.gov/pubmed/33523837
http://dx.doi.org/10.1126/sciadv.abc2100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775773/
https://www.ncbi.nlm.nih.gov/pubmed/33523837
http://dx.doi.org/10.1126/sciadv.abc2100

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