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Synthetic lethality across normal tissues is strongly associated with cancer risk, onset, and tumor suppressor specificity
Various characteristics of cancers exhibit tissue specificity, including lifetime cancer risk, onset age, and cancer driver genes. Previously, the large variation in cancer risk across human tissues was found to strongly correlate with the number of stem cell divisions and abnormal DNA methylation l...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775773/ https://www.ncbi.nlm.nih.gov/pubmed/33523837 http://dx.doi.org/10.1126/sciadv.abc2100 |