Ultradeep sequencing differentiates patterns of skin clonal mutations associated with sun-exposure status and skin cancer burden

In ultraviolet (UV) radiation–exposed skin, mutations fuel clonal cell growth. The relationship between UV exposure and the accumulation of clonal mutations (CMs) and the correlation between CMs and skin cancer risk are largely unexplored. We characterized 450 individual-matched sun-exposed (SE) and...

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Detalles Bibliográficos
Autores principales: Wei, Lei, Christensen, Sean R., Fitzgerald, Megan E., Graham, James, Hutson, Nicholas D., Zhang, Chi, Huang, Ziyun, Hu, Qiang, Zhan, Fenglin, Xie, Jun, Zhang, Jianmin, Liu, Song, Remenyik, Eva, Gellen, Emese, Colegio, Oscar R., Bax, Michael, Xu, Jinhui, Lin, Haifan, Huss, Wendy J., Foster, Barbara A., Paragh, Gyorgy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775785/
https://www.ncbi.nlm.nih.gov/pubmed/33523857
http://dx.doi.org/10.1126/sciadv.abd7703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775785/
https://www.ncbi.nlm.nih.gov/pubmed/33523857
http://dx.doi.org/10.1126/sciadv.abd7703

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