1616. Mechanism of Thrombocytopenia Induced by Oxazolidinones Antibiotics (Linezolid, Tedizolid): Demonstration of Impairment of Megakaryocyte Differentiation From Human Hematopoietic Stem Cells associated with Mitochondrial Toxicity

BACKGROUND: Linezolid causes thrombocytopenia, which limits its use. In cell culture and in tissues from treated patients, linezolid impairs mitochondrial protein synthesis (due to structural similarities and common binding sites between bacterial and mitochondrial ribosomes). Recent studies have sh...

Descripción completa

Detalles Bibliográficos
Autores principales: Tulkens, Paul M, Milosevic, Tamara V, Vertenoeil, Gaëlle, Vainchenker, William, Constantinescu, Stefan N, Van Bambeke, Françoise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Poster Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7776155/
http://dx.doi.org/10.1093/ofid/ofaa439.1796

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7776155/
http://dx.doi.org/10.1093/ofid/ofaa439.1796

Ejemplares similares