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1616. Mechanism of Thrombocytopenia Induced by Oxazolidinones Antibiotics (Linezolid, Tedizolid): Demonstration of Impairment of Megakaryocyte Differentiation From Human Hematopoietic Stem Cells associated with Mitochondrial Toxicity
BACKGROUND: Linezolid causes thrombocytopenia, which limits its use. In cell culture and in tissues from treated patients, linezolid impairs mitochondrial protein synthesis (due to structural similarities and common binding sites between bacterial and mitochondrial ribosomes). Recent studies have sh...
Autores principales: | Tulkens, Paul M, Milosevic, Tamara V, Vertenoeil, Gaëlle, Vainchenker, William, Constantinescu, Stefan N, Van Bambeke, Françoise |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7776155/ http://dx.doi.org/10.1093/ofid/ofaa439.1796 |
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