Desialylation of O-glycans on glycoprotein Ibα drives receptor signaling and platelet clearance

During infection neuraminidase desialylates platelets and induces their rapid clearance from circulation. The underlying molecular basis, particularly the role of platelet glycoprotein (GP)Ibα therein, is not clear. Utilizing genetically altered mice, we report that the extracellular domain of GPIbα...

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Detalles Bibliográficos
Autores principales: Wang, Yingchun, Chen, Wenchun, Zhang, Wei, Lee-Sundlov, Melissa M., Casari, Caterina, Berndt, Michael C., Lanza, Francois, Bergmeier, Wolfgang, Hoffmeister, Karin M., Zhang, X. Frank, Li, Renhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7776245/
https://www.ncbi.nlm.nih.gov/pubmed/31974202
http://dx.doi.org/10.3324/haematol.2019.240440

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7776245/
https://www.ncbi.nlm.nih.gov/pubmed/31974202
http://dx.doi.org/10.3324/haematol.2019.240440

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