Cargando…

Desialylation of O-glycans on glycoprotein Ibα drives receptor signaling and platelet clearance

During infection neuraminidase desialylates platelets and induces their rapid clearance from circulation. The underlying molecular basis, particularly the role of platelet glycoprotein (GP)Ibα therein, is not clear. Utilizing genetically altered mice, we report that the extracellular domain of GPIbα...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yingchun, Chen, Wenchun, Zhang, Wei, Lee-Sundlov, Melissa M., Casari, Caterina, Berndt, Michael C., Lanza, Francois, Bergmeier, Wolfgang, Hoffmeister, Karin M., Zhang, X. Frank, Li, Renhao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Fondazione Ferrata Storti 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7776245/ https://www.ncbi.nlm.nih.gov/pubmed/31974202 http://dx.doi.org/10.3324/haematol.2019.240440

Ejemplares similares

New insights into glycoprotein Ibα desialylation-mediated platelet clearance
por: Yule, Jack, et al.
Publicado: (2020)

Specific O-glycans in the mechanosensory domain of glycoprotein Ibα are important for its stability and function
por: Wang, Yingchun, et al.
Publicado: (2023)

Desialylated Platelet Clearance in the Liver is a Novel Mechanism of Systemic Immunosuppression
por: Li, June, et al.
Publicado: (2023)

Desialylation of platelet surface glycans enhances platelet adhesion to adsorbent polymers for lipoprotein apheresis
por: Lauková, Lucia, et al.
Publicado: (2020)

Platelet clearance via shear-induced unfolding of a membrane mechanoreceptor
por: Deng, Wei, et al.
Publicado: (2016)

Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia
por: Li, June, et al.
Publicado: (2015)

CD8(+) T cells induce platelet clearance in the liver via platelet desialylation in immune thrombocytopenia
por: Qiu, Jihua, et al.
Publicado: (2016)

Desialylation of platelets induced by Von Willebrand Factor is a novel mechanism of platelet clearance in dengue
por: Riswari, Silvita Fitri, et al.
Publicado: (2019)

Reduced platelet glycoprotein Ibα shedding accelerates thrombopoiesis and COX-1 recovery: implications for aspirin dosing regimen
por: Simeone, Paola, et al.
Publicado: (2022)

Autoantibody-mediated desialylation impairs human thrombopoiesis and platelet lifespan
por: Marini, Irene, et al.
Publicado: (2019)

Platelet desialylation and TFH cells–the novel pathway of immune thrombocytopenia
por: Chen, Yuwen, et al.
Publicado: (2021)

Antiplatelet antibody predicts platelet desialylation and apoptosis in immune thrombocytopenia
por: Zheng, Shiying Silvia, et al.
Publicado: (2022)

Platelet storage induces accelerated desialylation of platelets and increases hepatic thrombopoietin production
por: Cho, Jooyoung, et al.
Publicado: (2018)

Association of Platelet Desialylation and Circulating Follicular Helper T Cells in Patients With Thrombocytopenia
por: Chen, Yuwen, et al.
Publicado: (2022)

The Glycoprotein Ib-IX-V Complex Is a Platelet Counterreceptor for P-Selectin
por: Romo, Gabriel M., et al.
Publicado: (1999)

Platelet desialylation correlates with efficacy of first-line therapies for immune thrombocytopenia
por: Tao, Lili, et al.
Publicado: (2017)

Structural basis for the specific inhibition of glycoprotein Ibα shedding by an inhibitory antibody
por: Tao, Yue, et al.
Publicado: (2016)

A biotechnological tool for glycoprotein desialylation based on immobilized neuraminidase from Clostridium perfringens
por: Bidondo, Lucía, et al.
Publicado: (2021)

On the association of glycoprotein Ib and actin-binding protein in human platelets
Publicado: (1985)

P1669: AUTOANTIBODY-MEDIATED PLATELET DESIALYLATION IN ADULTS WITH PRIMARY IMMUNE THROMBOCYTOPENIA
por: Schramm, T., et al.
Publicado: (2022)

Desialylation is associated with apoptosis and phagocytosis of platelets in patients with prolonged isolated thrombocytopenia after allo-HSCT
por: Zhang, Xiao-Hui, et al.
Publicado: (2015)

Rasa3 deficiency minimally affects thrombopoiesis but promotes severe thrombocytopenia due to integrin-dependent platelet clearance
por: Lee, Robert H., et al.
Publicado: (2022)

Shear Stress Promotes Platelet Surface Desialylation, Platelet Count Drop, and Microvesiculation: Do Platelets Need to be Sugar-Coated?
por: Roka-Moiia, Yana, et al.
Publicado: (2022)

Kupffer cell receptor CLEC4F is important for the destruction of desialylated platelets in mice
por: Jiang, Yizhi, et al.
Publicado: (2021)

Platelet glycoprotein Ibα is an important mediator of ischemic stroke in mice
por: De Meyer, Simon F, et al.
Publicado: (2011)

Adhesion Maturation of Neutrophils on Nanoscopically Presented Platelet Glycoprotein Ibα
por: Kruss, Sebastian, et al.
Publicado: (2013)

Glycoprotein Ib activation by thrombin stimulates the energy metabolism in human platelets
por: Corona de la Peña, Norma, et al.
Publicado: (2017)

Essential role of zyxin in platelet biogenesis and glycoprotein Ib-IX surface expression
por: Yan, Rong, et al.
Publicado: (2021)

Platelet Glycoprotein Ibα Is a Counterreceptor for the Leukocyte Integrin Mac-1 (Cd11b/Cd18)
por: Simon, Daniel I., et al.
Publicado: (2000)

Membrane skeleton orchestrates the platelet glycoprotein (GP) Ib‐IX complex clustering and signaling
por: Shang, Dan, et al.
Publicado: (2016)

von Willebrand Factor and Platelet Glycoprotein Ib: A Thromboinflammatory Axis in Stroke
por: Denorme, Frederik, et al.
Publicado: (2019)

Platelet Desialylation Is a Novel Mechanism and Therapeutic Target in Daboia siamensis and Agkistrodon halys Envenomation-Induced Thrombocytopenia
por: Zhang, Cheng, et al.
Publicado: (2022)

Glycan analysis of therapeutic glycoproteins
por: Zhang, Lei, et al.
Publicado: (2015)

Relevance of platelet desialylation and thrombocytopenia in type 2B von Willebrand disease: preclinical and clinical evidence
por: Dupont, Annabelle, et al.
Publicado: (2019)

Sialic acid and platelet count regulation: Implications in immune thrombocytopenia
por: Lee‐Sundlov, Melissa M., et al.
Publicado: (2022)

Targeting Platelet–Leukocyte Interactions: Identification of the Integrin Mac-1 Binding Site for the Platelet Counter Receptor Glycoprotein Ibα
por: Ehlers, Raila, et al.
Publicado: (2003)

Desialylated transferrin in plasma of patients with migraine without aura
por: Launay, Jean-Marie, et al.
Publicado: (2000)

Desialylation of lysosomal membrane glycoproteins by Trypanosoma cruzi: a role for the surface neuraminidase in facilitating parasite entry into the host cell cytoplasm
Publicado: (1992)

Blocking of platelet glycoprotein receptor Ib reduces “thrombo-inflammation” in mice with acute ischemic stroke
por: Schuhmann, Michael K., et al.
Publicado: (2017)

The complexity of glycoprotein-derived glycans
por: VLIEGENTHART, Johannes F. G.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ota4g29fcvvebpht01r6kr0i8p