Cargando…

Autoantibody-mediated desialylation impairs human thrombopoiesis and platelet lifespan

Immune thrombocytopenia is a common bleeding disease caused by autoantibody-mediated accelerated platelet clearance and impaired thrombopoiesis. Accumulating evidence suggests that desialylation affects platelet lifespan in immune thrombocytopenia. Herein, we report on novel effector functions of au...

Descripción completa

Detalles Bibliográficos
Autores principales:	Marini, Irene, Zlamal, Jan, Faul, Christoph, Holzer, Ursula, Hammer, Stefanie, Pelzl, Lisann, Bethge, Wolfgang, Althaus, Karina, Bakchoul, Tamam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Fondazione Ferrata Storti 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7776251/ https://www.ncbi.nlm.nih.gov/pubmed/31857361 http://dx.doi.org/10.3324/haematol.2019.236117

Ejemplares similares

Antibody‐mediated procoagulant platelet formation in COVID‐19 is AKT dependent
por: Pelzl, Lisann, et al.
Publicado: (2022)

Platelet phosphatidylserine is the critical mediator of thrombosis in heparin-induced thrombocytopenia
por: Zlamal, Jan, et al.
Publicado: (2023)

Inhibition of GPIb-α-mediated apoptosis signaling enables cold storage of platelets
por: Marini, Irene, et al.
Publicado: (2023)

Antibody-induced procoagulant platelets in severe COVID-19 infection
por: Althaus, Karina, et al.
Publicado: (2021)

Antibody‐mediated platelet activation in COVID‐19: A coincidence or a new mechanism of the dysregulated coagulation system?
por: Althaus, Karina, et al.
Publicado: (2021)

Immune-Mediated Platelet Activation in COVID-19 and Vaccine-Induced Immune Thrombotic Thrombocytopenia
por: Uzun, Günalp, et al.
Publicado: (2022)

P1669: AUTOANTIBODY-MEDIATED PLATELET DESIALYLATION IN ADULTS WITH PRIMARY IMMUNE THROMBOCYTOPENIA
por: Schramm, T., et al.
Publicado: (2022)

The interaction between anti-PF4 antibodies and anticoagulants in vaccine-induced thrombotic thrombocytopenia
por: Singh, Anurag, et al.
Publicado: (2022)

Upregulation of cAMP prevents antibody-mediated thrombus formation in COVID-19
por: Zlamal, Jan, et al.
Publicado: (2022)

Platelet-neutrophil interaction in COVID-19 and vaccine-induced thrombotic thrombocytopenia
por: Hirsch, Johannes, et al.
Publicado: (2023)

No Correlation between Anti-PF4 and Anti–SARS-CoV-2 Antibodies after ChAdOx1 nCoV-19 Vaccination
por: Uzun, Günalp, et al.
Publicado: (2021)

Cold storage of platelets in additive solution: the impact of residual plasma in apheresis platelet concentrates
por: Marini, Irene, et al.
Publicado: (2019)

BCL-2 is dispensable for thrombopoiesis and platelet survival
por: Debrincat, M A, et al.
Publicado: (2015)

Platelet desialylation and TFH cells–the novel pathway of immune thrombocytopenia
por: Chen, Yuwen, et al.
Publicado: (2021)

Antiplatelet antibody predicts platelet desialylation and apoptosis in immune thrombocytopenia
por: Zheng, Shiying Silvia, et al.
Publicado: (2022)

Platelet storage induces accelerated desialylation of platelets and increases hepatic thrombopoietin production
por: Cho, Jooyoung, et al.
Publicado: (2018)

Desialylation of platelet surface glycans enhances platelet adhesion to adsorbent polymers for lipoprotein apheresis
por: Lauková, Lucia, et al.
Publicado: (2020)

Platelet desialylation correlates with efficacy of first-line therapies for immune thrombocytopenia
por: Tao, Lili, et al.
Publicado: (2017)

New insights into glycoprotein Ibα desialylation-mediated platelet clearance
por: Yule, Jack, et al.
Publicado: (2020)

Association of Platelet Desialylation and Circulating Follicular Helper T Cells in Patients With Thrombocytopenia
por: Chen, Yuwen, et al.
Publicado: (2022)

Desialylated Platelet Clearance in the Liver is a Novel Mechanism of Systemic Immunosuppression
por: Li, June, et al.
Publicado: (2023)

Desialylation of platelets induced by Von Willebrand Factor is a novel mechanism of platelet clearance in dengue
por: Riswari, Silvita Fitri, et al.
Publicado: (2019)

CD8(+) T cells induce platelet clearance in the liver via platelet desialylation in immune thrombocytopenia
por: Qiu, Jihua, et al.
Publicado: (2016)

Fibrinolysis shut down in COVID-19 patients: Report on two severe cases with potential diagnostic and clinical relevance
por: Bakchoul, Tamam, et al.
Publicado: (2020)

Multiphoton In Vivo Microscopy of Embryonic Thrombopoiesis Reveals the Generation of Platelets through Budding
por: Liu, Huan, et al.
Publicado: (2023)

Toll-like Receptors and Thrombopoiesis
por: Tang, Xiaoqin, et al.
Publicado: (2023)

Treatment of drug-induced immune thrombocytopenias
por: Marini, Irene, et al.
Publicado: (2022)

Hypofibrinolysis in pediatric patients with veno-occlusive disease in hematopoietic stem cell transplantation
por: Schneider, Veronika, et al.
Publicado: (2023)

Shear Stress Promotes Platelet Surface Desialylation, Platelet Count Drop, and Microvesiculation: Do Platelets Need to be Sugar-Coated?
por: Roka-Moiia, Yana, et al.
Publicado: (2022)

Desialylation of O-glycans on glycoprotein Ibα drives receptor signaling and platelet clearance
por: Wang, Yingchun, et al.
Publicado: (2020)

Kupffer cell receptor CLEC4F is important for the destruction of desialylated platelets in mice
por: Jiang, Yizhi, et al.
Publicado: (2021)

Autoimmune Heparin-Induced Thrombocytopenia after Transcatheter Aortic Valve Implantation: Successful Treatment with Adjunct High-Dose Intravenous Immunoglobulin
por: Bakchoul, Tamam, et al.
Publicado: (2019)

Apoptosis in megakaryocytes: Safeguard and threat for thrombopoiesis
por: Yang, Shuo, et al.
Publicado: (2023)

Beta-Glycerophosphate-Induced ORAI1 Expression and Store Operated Ca(2+) Entry in Megakaryocytes
por: Pelzl, Lisann, et al.
Publicado: (2020)

Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia
por: Li, June, et al.
Publicado: (2015)

Desialylation is associated with apoptosis and phagocytosis of platelets in patients with prolonged isolated thrombocytopenia after allo-HSCT
por: Zhang, Xiao-Hui, et al.
Publicado: (2015)

IL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs
por: Nishimura, Satoshi, et al.
Publicado: (2015)

Relevance of platelet desialylation and thrombocytopenia in type 2B von Willebrand disease: preclinical and clinical evidence
por: Dupont, Annabelle, et al.
Publicado: (2019)

Thrombopoiesis is spatially regulated by the bone marrow vasculature
por: Stegner, David, et al.
Publicado: (2017)

Effect of Simvastatin on Thrombopoiesis in Porcine Bone Marrow
por: Snarska, Anna, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_eu29khdvim64b4u5apbedku7cf