1256. In Vivo Activity and Structural Characterization of a New Generation γ-Lactam Siderophore Antibiotic Against Multidrug-Resistant Gram-Negative Bacteria and Acinetobacter spp

BACKGROUND: Multidrug-resistant (MDR) A. baumannii presents a critical need for innovative antibacterial development. We have identified a new series of γ-lactam (oxopyrazole) antibiotics that target penicillin binding proteins (PBPs) and incorporate a siderophore moiety to facilitate periplasmic up...

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Detalles Bibliográficos
Autores principales: Goldberg, Joel, Bethel, Christopher, Hujer, Andrea M, Marshall, Steven, Taracila, Magdalena A, Papp-Wallce, Krisztina M, Kumar, Vijay, van den Akker, Focco, Plummer, Mark, Bonomo, Robert A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Poster Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7776719/
http://dx.doi.org/10.1093/ofid/ofaa439.1440

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7776719/
http://dx.doi.org/10.1093/ofid/ofaa439.1440

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