1250. Novel Boronic Acid Transition State Analogs (BATSI) with in vitro inhibitory activity against class A, B and C β-lactamases

BACKGROUND: Catalytic mechanisms of serine β-lactamases (SBL; classes A, C and D) and metallo-β-lactamases (MBLs) have directed divergent strategies towards inhibitor design. SBL inhibitors act as high affinity substrates that -as in BATSIs- form a reversible, dative covalent bond with the conserved...

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Detalles Bibliográficos
Autores principales: Mojica, Maria F, Bethel, Christopher, Caselli, Emilia, Taracila, Magdalena A, Prati, Fabio, Bonomo, Robert A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Poster Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7776999/
http://dx.doi.org/10.1093/ofid/ofaa439.1434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7776999/
http://dx.doi.org/10.1093/ofid/ofaa439.1434

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