HIV proviral DNA integration can drive T cell growth ex vivo

In vivo clonal expansion of HIV-infected T cells is an important mechanism of viral persistence. In some cases, clonal expansion is driven by HIV proviral DNA integrated into one of a handful of genes. To investigate this phenomenon in vitro, we infected primary CD4+ T cells with an HIV construct ex...

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Detalles Bibliográficos
Autores principales: Yoon, John K., Holloway, Joseph R., Wells, Daria W., Kaku, Machika, Jetton, David, Brown, Rebecca, Coffin, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7777207/
https://www.ncbi.nlm.nih.gov/pubmed/33318172
http://dx.doi.org/10.1073/pnas.2013194117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7777207/
https://www.ncbi.nlm.nih.gov/pubmed/33318172
http://dx.doi.org/10.1073/pnas.2013194117

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